Report an error   


Submitted: 16 August 2011
HERDIN Record #: PCHRD08161110083853

Comparative study of drug-resistant Mycobacterium tuberculosis in socio-economically depressed urban and rural communities in the Philippines- Part II: Drug resistance pattern of Mycobacterium tuberculosis.

Adelwisa R. Ortega

See More

Three hundred sixty one (361) sputum specimens were collected from TB symptomatics and TB suspects from Aguinaldo, Cavite, Dagat-Dagatan, Malabon and Malinta, Valenzuela. All specimens were cultured for Mycobacterium tuberculosis and examined for acid fast bacilli using direct sputum microscopy. A total of 10.2% positive culture were obtained and 14.51% of these came from (+) AFB specimens and 85.49% from the (-) AFB sputa. However, only 45.9% of the cultures were Mycobacterium tuberculosis. Sensitivity testing was performed on 58.8% of the TB isolates and 50% of these were found to have resistance to Isoniazid, Rifampicin, Ethionamide, Ethambutol, Streptomycin and PAS. Moreover, M. tuberculosis with one drug-resistance, i.e. to INH was 20 to two-drugs, namely INH/Ethionamide is 10% and 10 to PAS/Ethambutol. Ten percent had three-drug resistance, and this is to INH/PAS/Rifampicin. Total resistance to INH was 40%, 20% to PAS and 10% to Rifampicin, Ethionamide and Ethambutol. However, no resistance to Streptomycin was found in contrast to the results of previous studies.

Publication Type
Research Project
Date
November 30, 1988-November 30, 1991

Objectives

To determine the prevalence of INH-resistant pulmonary tuberculosis in urban and rural poor communities in the Philippines. Specifically it aimed to: (1) determine the extent of the problem of INH-resistant Mycobacterium tuberculosis in communities where the disease is most common; (2) find the effectivity of other chemotherapeutic drug and some herbal medicines on Mycobacterium tuberculosis and (3) determine the level of knowledge, attitudes and perceptions of people residing in the stated communities on tuberculosis.

LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Library Abstract Print Format (Request Document)