Report an error   


Submitted: 16 May 2007 Modified: 12 April 2018
HERDIN Record #: PCHRDPC040649

Gastric cancer in Filipino patients: Survival after surgery.

Samuel D. Ang,
Roel S. Tolentino ,
Benito Tan,
Deogracias Alberto G. Reyes

See More

OBJECTIVES: The primary objectives of this study were to review and describe the profile of a subset of Filipino patients with gastric cancer, to determine the overall survival and disease-free survival according to stage, as well as the effect of surgery and different adjuvant treatments on the survival of these patients.


METHODS: Reviewed were the clinical records of 125 gastric cancer patients seen by the authors from September 1985 to June 2001 in four hospitals in Metro Manila. Of the 125 cases, 81 patients operated for gastric adenocarcinoma with a minimum of two years follow-up or with recurrence or death within two years were included.


RESULTS: The mean age of the patients was 60 years (range=27 to 82 years), with a male to female ratio of 1.4:1. The median follow-up of the patients was 14 months (range=1.5 to 131 months). The tumors were in the body of the stomach in 53 percent and 52 percent of them were poorly differentiated. Total gastrectomy was the most common operation done (30/81). The liver was the most common site of recurrence (36 percent). The 5-year overall survival rates for stage I, II, III, and IV were 100 percent, 80 percent, 30 percent and 0, respectively. Likewise the 5-year disease-free survival rates for stage I, II, and III were 100 percent, 80 percent and 42 percent, respectively.


CONCLUSION: We found that subtotal gastrectomy was associated with a significantly longer 5-year overall survival (p=0.0064, log rank test) compared to other gastric operations. Postoperative adjuvant treatment in general significantly prolonged the overall survival of stage IV patients (p=0.0017, log rank test).

Publication Type
Journal
Publication Sub Type
Journal Article, Original
Title
Philippine Journal of Surgical Specialties
Frequency
Quarterly
Publication Date
January-March 2003
Volume
58
Issue
1
Page(s)
1-8

Publication Type
Journal
Publication Sub Type
Journal Article, Original
Title
Philippine Journal of Oncology
Frequency
Semi-Annual
Publication Date
June 2004
Volume
5
Issue
1
Page(s)
14-20
LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Library Box No.6 Fulltext pdf (Request Document)
1. Cajucom, C. C., Hilvano, S. . Gastric cancer. In: Nuqui EY (ed): The Philippine Hanbook of Clinical Oncology Manila: Raintree Trading and Publishing, Inc, 2001. 104-112. (2nd ed.)
2. Karpeh, M. S., Kelsen, D. P., Tepper, J. E.. Cancer of the stomach. In: De Vita VT, Hellman S, Rosenberg SA (eds): Cancer - Principles and Practice of Oncology Philadelphia, USA: Lippincott Raven, 1997. 1092-1126. (6th ed.)
3. Roukos, D. H.. "Current status and future perspectives in gastric cancer management" Cancer Treat Rev 26(4): 243-245, 2000. Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/10913380
4. Gunderson, L. L., Sosin, H. . "Adenocarcinoma of the stomach: areas of failure in a re-operation series (second or symptomatic look) clinicopathologic correlation and implications for adjuvant therapy" Int J Radiat Oncol Biol Phys 8(1): 1-11, 1982. Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/7061243
5. Canga, G.A. C., Cabahug, E. O., Chan, K. S.. "Gastric adenocarcinoma: 15 years experience at Cebu Doctors Hospital" Philipp J Surg Spec 47(4): 155-159, 1992. Retrieved from: http://scinet.dost.gov.ph/union/ShowSearchResult.php?s=2&f=&p=&x=&page=&sid=1&id=Gastric+adenocarcinoma%3A+15+years+experience+at+Cebu+Doctors+Hospital&Mtype=ANALYTICS
6. Obenza, R. C., Lobo, R. P.. "Gastric carcinoma: a 7-year experience at the Davao Medical Center" Philipp J Surg Spec 53(3): 101-104, 1998
7. Laudico, A. V., Esteban, D. V., Reyes, L. M.. "Stomach cancer incidence in Metro Manila and Rizal province: 1980-1992" Philipp J Surg Spec 54(2): 67-73, 1999
8. Greene, F. L., Page, D. L., Fleming, I. D., et al., . AJCC cancer staging manual Philadelphia, USA: Lippincott Raven, 2002. 99-106. (6th ed)
9. Wang, C. S., Hsieh, C. C., Chao, T. C., et al., . "Resectable gastric cancer: operative mortality and survival analysis" Chang Gung Med J 25(4): 216-217, 2002. Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/12079155
10. Yoo, C. H., Noh, S. H., Shin, D. W., Choi, S. H., Min, J. S.. "Recurrence following curative resection for gastric carcinoma" Br J Surg 87(2): 236-242, 2000. Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/10671934
11. Hyung, H. W., Noh, S. H., Shin, D. W., et al., . "Adverse effect of perioperative transfusion on patients with stage III and IV gastric cancer" Ann Surg Oncol 9(1): 5-12, 2002. Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/11829431
12. Harrison, L. E., Karpeh, M. D., Brennan, M. F.. "Total gastrectomy is not necessary for proximal gastric cancer" Surgery 123(2): 127-130, 1998. Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/9481396
13. Bozzetti, F. , Marubini, E. , Bonfanti, G. , Miceli, R. , Piano, C. , Gennari, L. . "Subtotal versus total gastrectomy for gastric cancer: five year survival rates in a multi-center randomized Italian trial. Italian Gastrointestinal Tumor Study Group" Ann Surg 230(2): 170-178, 1999. Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/10450730
14. Pacelli, F. , Papa, V. , Caprino, P. , Sgadari, A. , Bossola, M. , Doglietto, G. B.. "Proximal compared with distal gastric cancer: multivariate analysis of prognostic factors" Am J Surg 67(7): 697-703, 2001. Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/11450793
15. Shiraishi, N. , Adachi, Y. , Kitano, S. , Kakisako, K. , Inomata, M. , Yasuda, K. . "Clinical outcome of proximal versus total gastrectomy for proximal gastric cancer" World J Surg 26(9): 2002. Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/12209245
16. Gotoda, D. , Sasako, M. , Ono, H. , Katai, H. , Sano, T. , Shimoda, T. . "Evaluation of the necessity for gastrectomy with lymph node dissection for patients with submucosal invasive gastrci cancer" Br J Surg 88(3): 444-449, 2001. Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/11260114
17. Kerpeh, M. S., Leon, L. , Klimstra, D. , Brennan, M. F.. "Lymph node staging in gastric cancer: is location more important than number? An analysis of 1308 patients" Ann Surg 232(3): 362-371, 2000
18. Roukos, D. H., Lorenz, M. , Encke, A. . "Evidence of survival benefit of extended (D2) lymphadenectomy in western patients with gastric cancer based on a new concept: a prospective long term follow-up study" Surgery 123(5): 573-578, 1998. Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/9591011
19. Ocana, L. F., Crocifoglio, V. , Sanchez, R. , Molina, J. M.. "Survival benefit of D2 lymphadenectomy in patients with gastric adenocarcinoma" Ann Surg Oncol 7(3): 210-217, 2000. Retrieved from: http://www.researchgate.net/publication/12525225_Survival_benefit_of_D2_lympadenectomy_in_patients_with_gastric_adenocarcinoma
20. Samson, P. S., Escovidal, L. A., Yrastorza, S. G., Veneracion, R. G., Nerves, M. Y.. "Re-study of gastric cancer: analysis of outcome" World J Surg 26(4): 428-433, 2002. Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/11910474
21. Kunisaki, C. , Shimada, H. , Nomura, M. , Akiyama, H. . "Appropriate lymph node dissection for early gastric cancer based on lymph node metastases" Surgery 129(2): 153-157, 2001. Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/11174707
22. Greene, F. L.. "Management of gastric remnant carcinoma based on the results of a fifteen year endoscopic screening program" Ann Surg 223(6): 701-708, 1996. Retrieved from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1235215/
23. Fisher, S. G., Davi, F. , Nelson, R. , et al., . "A cohort study of cancer risk in man after gastric surgery for benign disease " J Natl Cancer Inst 85(16): 1303-1310, 1993. Retrieved from: http://jnci.oxfordjournals.org/content/85/16/1303.short
24. Bonenkamp, J. J., Hermans, J. , Sasako, M. , van de Velde, C. J.. "Extended lymph node dissection for gastric cancer" Dutch Gastric cancer Group. N Rngl J Med 340(12): 908-914, 1999. Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/10089184
25. Wanebo, H. J., Kennedy, B. J., Chemiel, J. , Steele Jr., G. , Winchester, D. , Osteen, R. . "Cancer of the stomach: a patient care study by the American College of Surgeons" Ann Surg 218(5): 583-592, 1993. Retrieved from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1243028/
26. Maruyama, K. , Okabayashi, K. , Kinoshita, T. . "Progress in gastric cancer surgery in Japan and its limits of radicality" World J Surg 11(4): 418-425, 1987. Retrieved from: http://www.springerlink.com/content/u7k09222354738r8/