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Submitted: 16 August 2019 Modified: 22 August 2019
HERDIN Record #: 102255-19081616085089

The comparison between management recommendations of the Neonatal Early Onset Sepsis Calculator and CDC/AAP Guidelines among culture-proven early onset sepsis admitted at University of East Ramon Magsaysay Memorial Medical Center from January 2013 to December 2017.

Angelia Septiane Beandda,
Katherine Mae A. Doctor

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Introduction Early onset sepsis is difficult to diagnose due to nonspecific symptoms and a lack of
reliable tests. It can progress quickly, and lead to neurodevelopmental consequences or be fatal if not
treated. However, approximately 10-fold more newborns are treated with antibiotics empirically and often
unnecessarily. This study aimed to compare the management recommendations of the Neonatal Early
Onset Sepsis Calculator with those of the Centers for Disease Control/American Academy of Pediatrics
guidelines.



Methods Neonatal Early Onset Sepsis Calculator was applied to the data set to examine how an alternative
model would perform compared to current guidelines published by the CDC and compared to current
practice within the institution. Chi square and kappa value agreement was used to determine the difference
between treatment recommendations of NEOS calculator and AAP guideline.



Results Of the 330 patients who received therapy, only 14.2% were recommended empiric antibiotics by
the EOS calculator, compared to the 39% recommended by the CDC guidelines (p < 0.001, К = 0.372).
Eleven patients were identified to have culture-positive sepsis.



Conclusion The number of infants suspected with EOS and subsequently require antibiotic use at birth
may be dramatically reduced with the use of the neonatal EOS calculator.

Publication Type
Journal
Publication Sub Type
Journal Article, Original
Title
The Health Sciences Journal
Frequency
Semi-Annual
Publication Date
January-June 2019
Volume
8
Issue
1
Page(s)
20-28
LocationLocation CodeAvailable FormatAvailability
UERMMMC Fulltext Print Format

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