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Submitted: 24 December 2018 Modified: 24 December 2018
HERDIN Record #: CAR-CRHRDC-18122407080881

Formulation and evaluation of the antioxidant capsule from the dried leaves of Sayote (Sechium edule, Family Cucurbitaceae).

Eva Marie B. Pascual,
Krista Ruth C. Boleyley,
Jasmin  K. Calica,
Hector B. De Vera,
Ericka R. Sayson,
Xean Andrei D. Viernes

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Antioxidants are man-made or natural substances that may prevent or delay some types of cell damage. Antioxidants are found in many foods, including fruits and vegetables. They are also available as dietary supplements. Examples of antioxidants includeBeta-carotene, Lutein, Lycopene, Selenium, Vitamin A, Vitamin C, and Vitamin E. Vegetables and fruits generally containing flavonoids are rich sources of antioxidants. There is good evidence that eating a diet with lots of vegetables and fruits is healthy and lowers risks of certain diseases. But it isn't clear whether this is because of the antioxidants, something else in the foods, or other factors.The purpose of this research is to identify the antioxidant property of the plant "Chayote" (Sechiumedule, Family Cucurbitaceae).Chayote is a tropical perennial vine, with stems climbing to 40 feet high. Rootstock is tuberous. Leaf petioles are 6 inches long. Leaves are hairy, broadly cordate, entire or angled, 10 to 20 centimeters long. Flowers are staminate, yellowish to pale green, in longracemes. Pistillate flowers are solitary, corolla 12 to 17 millimeters. Fruit is pear-shaped, light green, and slightly wrinkled or with shallow, narrow, longitudinal grooves, in some forms set with soft spines. Seed is single, large, with a smooth testa, clinging to the flesh, protruding from the fruit apex. The study tested the presence of flavonoids on the dried leaves of the Chayote which is responsible for the antioxidant activity of the said extract. Furthermore, the study formulated a capsule of different concentrations in mg (250, 500, 750, 1000) and its antioxidant activity was tested by In Vitro Lipid Peroxidation ,DPPH (2,2-diphenyl-1-1-picrylhydrazyl)Capacity Assay and a Dissolution test was done. The study revealed that the different concentrations from the powdered sayote exhibited anti-oxidant activity as absorbed from the conducted DPPH assay and in vitro lipid peroxidation test. The 750 mg concentration exhibited the best anti-oxidant activity as indicated by lowest absorbance reading in both DPPH assay and in vitro lipid peroxidation test. The 250mg capsule obtained the highest rate of absorption indicated by having the fastest time of dissolution, and the 1000mg capsule obtained the lowest rate of absorption due to obtaining the slowest rate of dissolution.

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