The anti-hyperglycemic and anti-hyperlipidemic activity of Ashitaba (Angelica keskei) was tested. The Ashitaba leaves were made into extracts with different concentrations which were administered to sugar solution-induced rabbits. A cholesterol meter measured blood cholesterol levels for baseline levels, induced cholesterol readings and reduced cholesterol levels and glucometer measured blood glucose levels. This study involved the analysis of the constituents and functions of Ashitaba (Angelica keskei) in lowering glucose and cholesterol levels using sugar solution-induced rabbits. It determined the most effective concentration of Ashitaba that exerted greatest anti-hyperglycemic and anti-hyperlipidemic effects. The anti-hyperglycemic and anti-hyperlipidemic activity of Ashitaba was determined after administration of the extracts after performing two tests. The study proved that Ashitaba is effective in lowering blood glucose level and cholesterol level. It showed that the best concentration in lowering blood glucose level and cholesterol level is 10% Ashitaba concentration.