Topical anti-inflammatory medications have been reported to be effective at treating pain associated with: acute injury, rheumatoid arthritis, breast pain, and episiotomy pain. Inflammation is neither a disease nor a kind of infection but it is a vital part of a healthy immune response. When our immune system overreacts to an irritant, there is a biological response trying to remove it leading to signs and symptoms of inflammation. The researchers studied the three natural plants atsuete (Bixa orellana, Bixaceae), coconut oil (Cocos nucifera, Arecaceae) and turmeric (Curcuma longa, Zingeberaceae) to determine the synergistic effect of the natural plants. Each plant alone has its own anti-inflammatory effect. The researchers formulated a liniment that can be used to reduce inflammation. The researchers mixed the three extracts together to determine whether they can shorten the duration in decreasing the size of inflammation. Four formulated liniments with different concentrations is as follows: Liniment A with the proportion of 1:1:1, liniment B with the proportion of 2:1:1, liniment C with the proportion of 1:2:1, liniment D with the proportion of 1:1:2 as to atsuete: turmeric: virgin coconut oil, respectively. The formulated liniments were made by mixing different proportions of ether extracts from turmeric, aqueous extracts from atsuete and the virgin oil from coconut in a mortar and pestle. This study focuses on the anti-inflammatory activity of the three plant extracts formulated as a liniment to work synergistically and elicit an anti-inflammatory effect. Carrageenan solution was injected to the 15 white rats to induce edema, and then application of the formulated liniments A, B, C and D topically. The result showed that all of the formulated liniments decreased the size of the induced edema and there were no significant differences as to the comparison with the positive control which is Omega® liniment. The study further showed that all the formulated liniments elicit their greatest action at different time intervals independently. Further studies on the formulation of a liniment that is more aesthetically appealing and finds a newer and more accurate approach in determining specific constituents of the three natural plants is suggested.