BACKGROUND: Kawasaki Disease is a self-limited childhood systemic vasculitis which may result to coronary artery aneurysm formation if diagnosis is missed and not appropriately treated. Diagnosis remains to be clinical with the support of laboratory findings.
OBJECTIVES: To determine clinical profile of Kawasaki Disease among 4 months to 18 year old patients admitted in CLMMRH, evaluate presenting symptoms, clinical course, laboratory test and treatment outcome.
METHODS: This was a descriptive retrospective chart review. Forty one cases of KawasakiDisease were determined from January 2011 to September 2015. Clinical data were recorded which include the demographic data, diagnostics and treatment. The treatment was compared to the development of coronary artery aneurysm of the patient. Chi-square was used to determine significant difference on factors correlated.
RESULTS: Of the 41 patients, all were determined to have typical Kawasaki Disease. Majority were male with highest incidence on ages 1-5 years old at 78.04%. Fever, conjunctivitis and mucocutaneous changes were seen in 100% of the patients. All patients had elevated ESR. Leucocytosis and thrombocytosis were seen in 70.58% and 53.0% respectively. All were given Aspirin; only 9 patients received IVIg. Seventeen had cardiac complications and only 1 developed coronary artery aneurysm. No significant difference was noted between treatment and development of coronary artery aneurysm.
CONCLUSION: All children fulfill the criteria for diagnosing Kawasaki Disease. Cardiac complications were seen in both patients given Aspirin alone and Aspirin + IVIg, one patient developed coronary artery aneurysm who received both. There was no significant difference in the treatment outcome among patients given IVIg and Aspirin versus Aspirin alone in the development of coronary artery aneurysm due to limited data
KEYWORDS. Kawasaki Disease, coronary artery aneurysm, IV Immunoglobulin