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Submitted: 25 July 2018 Modified: 25 July 2018
HERDIN Record #: R06-CLMMRH-18072513554141

Highly Active Anti-Retroviral Therapy associated Hyperglycemia and Dyslipidemia among Human Immunodeficiency Virus-Infected patients enrolled in Corazon Locsin Montelibano Memorial Regional Hospital: A cohort study.

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Background: According to the World Health Organization (WHO), Human Immunodeficiency Virus (HIV) has affected more than 34 million lives as of July 2015. Highly active anti-retroviral therapy (HAART) is the mainstay treatment for HIV patients. The prevalence of HAART-induced metabolic complications in the Philippines has not been well illustrated yet, and current WHO anti-retroviral therapy recommendations do not include lipid monitoring in patients receiving first-line regimen.  


Objective: Determine the prevalence of hyperglycemia and dyslipidemia among HIV-infected patients enrolled in Corazon Locsin Montelibano Memorial Regional Hospital (CLMMRH) Treatment Hub. 


Methodology. A descriptive observational study was conducted from January to August 2015 involving 137 registered living adult HIV patients of CLMMRH. Demographic data regarding age, sex, period with HIV infection, ART exposure, and anti-retroviral regimen were collected using a questionnaire. Medical records were used to confirm CD4 counts and calculate baseline body mass index (BMI). Tuberculosis were diagnosed via sputum microscopy and chest radiograph. Serum glucose and lipid profile were taken in 116 and monitored in 53 patients every 4 months for both HAART-naive and HAART-initiated groups.   


Results. Socio-demographics showed predominance of male sex, mostly belonged to 19-29 age group, BMI of 18.5-24.9 kg/m2, and CD4 counts


Conclusion. Dyslipidemia, specifically hypertriglyceridemia  and HDL-c hypocholesterolemia, is highly prevalent among HIV-infected patients of CLMMRH, both for HAART-naive and HAART-initiated groups, with increasing number of subjects especially on the HAART-group from January to August 2015. 

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Corazon Locsin Montelibano Memorial Regional Hospital Abstract Print Format

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