Report an error   


Submitted: 12 July 2018 Modified: 13 July 2018
HERDIN Record #: R04A-UPHBL-18071211123633

A COMPARATIVE IN VITRO EVALUATION OF THE EQUIVALENCE OF THREE GENERIC BRANDS OF MEFENAMIC ACID TABLETS.

1Leah M. Malapitan,
2Eduardo V. Soriano

Abstract

    Many different brands and dosage forms of acid are available in the Philippine market. It is important to comprehend the issues encompassing generic medicines versus the use of branded medicines. This attempt  the perception and credibility of generic drugs among providers, prescribers and consumers. Taking advantage of this action resulted in increased acceptance of generic medications and educating people of their equal efficacy.


    Qualitative and quantitative tests were done on two generic brands of mefenamic acid and an innovator brand to determine equivalence of the former to the latter. The qualitative tests were based on USP requirements and include diameter and thickness measurements, and weight uniformity, friablility, hardness and disintegration. For the quantitative tests, dissolution tests and determination of the mefenamic acid content of the tablets were done.


      Qualitatively, results showed that thare are significant differences between the generic brands and Mefenamic acid. Quantitative teste revealed that there are significant differences in the assay values and dissolution profile of the two  brands compared to innovator brand. However, the assay value of Brand to Brand C and the dissolution of Brand B to Brand C in phosphate buffer shoe no significant difference. This implies that the two generic brands are not equivalent. Based on the USP requirements, the two generic brand of mefenamic acid passed official in-vitro quality control tests prescribed for the tablets.


 

1.
Publication Type:
Journal
Publication Sub Type:
Journal Article, Original
Title:
UPH-Dr. Jose G. Tamayo Medical University/Medical Center
Frequency:
Annual
Publication Date:
2017
Volume:
8
Issue:
1
Page(s):
40-47
Publisher:
UPH-Dr. Jose G. Tamayo Medical University/Medical Center

1. Esteves, Patricia . "Watsons wants to educate consumers about choosing right generic drugs." The Philippine Star: Business , 2012 - [External Link]
2. Hailu, G.S. . "Comparative In vitro bioequivalence evalu of different brands of amoxicillin capsules marketed in Tigrau, Ethiopia" International Journal of Pharmaceutical Sciences and Nanotechnology 6(1): 22, 2013
3. Singal, G.L. , Nanda, A. , Kotwani, A . "A comparative evaluation of price and quality of some branded versus branded-generic medicines of the same manufacturer in India." Indian Journal of Pharmacology 23(2): 18, 2012