Health care-associated infection is a significant cause of illness in the health institution, and the blood pressure (BP-App) cuff is a potential source and vehicle of bacterial contaminants. This study is aimed at determining bacterial contamination and colonization that occur on BP-App cuffs, and the effectiveness of using plastic wrap in decreasing the microbial load. Forty patients of UPH-Dr. Jose G. Tamayo Medical Center were randomly divided into control and experimental groups. Plastic wrap was put around the arm of the patient prior to BP-App cuff placement for the experimental group. Results show that the bacterial counts of the control group were higher compared to the experimental group. A significant difference on the microbial cellular density readings between the control and the experimental groups was noted. This shows that prior application of clean wrap on the arm of the patient before taking blood pressure can significantly decrease number of microorganisms that colonize the BP-App cuff. Thus, health care workers should be educated that the BP-App cuff could transmit microorganisms from one patient to another; Hospital administrators should institute protocols that include regular decontamination of the BP-App cuff. A roll of clean wrap may be included in the admission kit of each patient to be applied on his/her arm before taking blood pressure.