Report an error   

Submitted: 05 July 2018 Modified: 17 August 2018
HERDIN Record #: NCR-SBU-18070514254990

Apple cider vinegar consumption as an adjunct therapy incontrolling blood glucose levels: A systematic review of its effect on glycemic profile.

Maria Reina  D. Abu,
Louise  C. Manangan,
Ranielle A. Ongoco,
Ryan  J. Pan,
Princess Mae  P. Pelisco ,
Mark  I. Reyes,
Christoffer  T. Samarista,
Dannah Jeanne J. Tagulao,
Joseph Christian  M. Tigas,
Gerben Villanueva,
Michael  Van Haute

See More

BACKGROUND: Diabetes appears to be a health issue in most countries specially here in the Philippines due to increasing population growth, aging, urbanization, and increasing prevalence of obesity and physical inactivity. Recently, the use of apple cider vinegar as a health remedy has been tremendously increasing. It is now widely used as an alternative medicine for systemic illnesses like hypercholesterolemia, hypertension and diabetes. The effect of vinegar on blood sugar levels is perhaps the best researched and the most promising of apple cider vinegar's possible health benefits. Several studies have found that vinegar may help lower glucose levels.  Some reports showed that vinegar affect the glucose and insulin responses to a sucrose or starch load.

OBJECTIVE:  The general objective of this study is to determine the relevance of regular intake of apple cider vinegar as an adjunct in controlling blood glucose levels. Specifically, it aims to assess the effect of apple cider vinegar on glycemic profile (fasting blood sugar, HbA1c) amongindividuals with or without comorbidities - based on the results of the studies included.

SELECTION CRITERIA: Only randomised and cross-over clinical trials in individuals were included. Interventions include apple cider vinegar at any dose or duration versus placebo, anyhypoglycemic agents, or no intervention. The trials could be double blind, single blind, or unblinded. Trials could be unpublished or published.

DATA COLLECTION AND ANALYSIS: Various electronic databases will be employed in this study which includes but not limited to PubMed, Medline, Clinical Key, Google Scholar, Cochrane, UpToDate; searched abstracts and lists of reviewed articles. Furthermore, reference lists of published studies and review articles will also be searched manually for additional studies. Studies included were from 2010 up to 2017 regardless of publication and language. A criterion of methodological quality will be used to assess and appraise the clinical trials included in this study. The Review Manager 5.3 will be used to assess weighted mean difference using 95% confidence interval.

Publication Type
Research Report
March 7, 2018

Publication Type
Research Report
LocationLocation CodeAvailable FormatAvailability
San Beda University - Health Sciences Library Fulltext
1. (2006, November 30). Centers for Disease Control and Prevention (July 25). Type 2 Diabetes.
2. Halima, B. H. , Sarra , K. , Mohamed, S. , Louay, T. , Fethi, B. S. , Houda, B. J. , Abdallah, A. . "Apple cider vinegar ameliorates hyperglycemia and hyperlipidemia in Tunisian type 2 diabetic patients" Int. J. of Multidisciplinary and Current research 5, 2007
3. Jimeno, C. A. , Kho, S. A. , Matawaran, B. J. , Duante, C. A. , Jasul, G. V. . "Prevalence of diabetes mellitus and pre-diabetes in the Philippines: A sub-study of the 7th National Nutrition and Health Survey (2008)" Philipp J Int Med 53(2): 1-8, 2015
4. Johnston, C. S. , Quagliano, S. , White, S. . "Vinegar ingestion at mealtime reduced fasting blood glucose concentrations in healthy adults at risk for type 2 diabetes" Journal of Functional Foods 5(4): 2007-2011, 2013
5. Liu, Z. , Yao, Z. , Li, C. , Liu, X. , Chen, H. , Gao, C. . "A step-by-step guide to the systematic review and metaanalysis of diagnostic and prognostic test accuracy evaluations" British journal of cancer 108(11): 2299, 2013
6. McCulloch, D. K. . (2016, November 30). Clinical presentation and diagnosis of diabetes mellitus in adults. U: UpToDate, Mulder JE ur. UpToDate [Internet]. Waltham, MA: UpToDate.
7. Mitrou, P. , Raptis, A. E. , Lambadiari , V. , Boutati, E. , Petsiou, E. , Spanoudi, F. , Raptis, S. A. . "Vinegar decreases postprandial hyperglycemia in patients with type 1 diabetes" Diabetes Care 33(2): e27-e27, 2010
8. Nazni, P. , Singh, R. , Shobana Devi, R. , Singh, H. , Singh, S. , Singh, K. , Kumar, S. . "Assessment of hypoglycemic effects of apple cider vinegar in type 2 diabetes" International Journal of Food and Nutritional Sciences 4(1): 206-209, 2015
9. Panetta, C. J. , Jonk, Y. C. , Shapiro, A. C. . "Prospective randomized clinical trial evaluating the impact of vinegar on lipids in non-diabetics" World Journal of Cardiovascular Diseases 3(02): 191, 2013
10. Quagliano, S. . Vinegar. 2013. (PhD) Arizona State University,
11. Salbe, A. D , Johnston, C. S. , Buyukbese, M. A. , Tsitouras, P. D. , Harman, S. M. . "Vinegar lacks antiglycemic action on enteral carbohydrate absorption in human subjects" Nutrition research 29(12): 846- 849, 2009
12. Shishehbor, F. , Mansoori, A. , Shirani, F. . "Vinegar consumption can attenuate postprandial glucose and insulin responses; a systematic review and meta-analysis of clinical trials" diabetes research and clinical practice 127, 1-9, 2017
13. Tan, G. H. . "Diabetes Care in the Philippines" Annals of Global Health 81(6): 863-869 do, 2015
14. White, A. M. . The efficacy of vinegar as adjunct therapy in glucose management in adults with type 2 diabetes. 2007. (PhD) Arizona State University,
15. White, A. M , Johnston, C. S. . "Vinegar ingestion at bedtime moderates waking glucose concentrations in adults with well-controlled type 2 diabetes" Diabetes Care 30(11): 2814-2815, 2007

Copyright © One Window Project 2018. All rights reserved.