Context/Background: This analytical cross-sectional research explores an aspect of human behavior in dealing with sickness. It is particularly interested in medical students of Cebu Institute of Medicine and their practices related to the use of antibiotics to relieve common signs and symptoms of a disease. Do they go see a doctor, like everyone is encouraged to, or do they take matters into their own hands? Antibiotic self-medication in itself is a risky habit because of the possibility of misdiagnosing one's own condition and subsequently taking the wrong medication for it. More importantly, it might add to the already rapidly growing number of antibiotic-resistant organisms. This study aims to look into the knowledge and compliance of this basic medication protocol by the future doctors in CIM, who ought to have a basic understanding of these consequences. Does this phenomenon occur significantly per year level? Are there other related demographics that contribute to the frequency antibiotic self-medication? Objective: To determine the prevalence of antibiotic self-medication among medical students of the Cebu Institute of Medicine in the academic year 2014 to 2015. Study Design: Analytical cross-sectional study. Study Setting: Cebu Institute of Medicine, F. Ramos Street, Cebu City. Study Population: First year to third year students enrolled in CIM for the academic year 2014 to 2015. Maneuver: Self-report of antibiotic self-medication practices through a questionnaire. Outcome Measures: Determine the demographic profile (age, sex, year level, and undergraduate degree); determine the prevalence of self-medication with antibiotics among different year levels; compare the different antibiotic self-medication practices among year levels (indications for use of antibiotics, duration of antibiotic self-medication, frequency of antibiotic self-medication, possible causes, type of antibiotic and corresponding dose, route of administration,source of antibiotics for self-medication, and adverse effects experienced, if any: determine the association between year level in medical school and the tendency to self-medicate with antibiotics.