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Submitted: 12 July 2016 Modified: 19 July 2016
HERDIN Record #: NCR-JAFES-16071216113388

Impact of a gluten-free diet on several growth parameters in children with type 1 diabetes mellitus and celiac disease in Western Uttar, Pradesh.

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Background. Celiac disease is frequently associated with uncontrolled blood sugar and impaired linear growth in a child with type 1 diabetes mellitus.


Objective. To study the impact of a gluten-free diet on several growth parameters in children with type 1 diabetes mellitus and celiac disease.


Methodology. Two hundred and fifty six patients with Type 1 diabetes mellitus were screened (149 males and 107 females) during the study period of two years. Patients were evaluated for the clinical signs, biochemical investigations and family history of celiac disease in a tertiary care health centre in Western Uttar Pradesh, India.


Results. Twenty four (9.3%) patients were diagnosed to have celiac disease; the mean age at diagnosis of diabetes was 9.37±7 years. Only one out of twenty four patients with celiac disease had been diagnosed before the detection of diabetes mellitus. Weight standard deviation score (SDS) increased from -0.12±1.3 at the start of gluten free diet to 0.8±0.9 after 12 months (p<0.004). Height SDS decreased from -2.46±1.1 at the start of gluten free diet to -2.14±0.9 after 12 months later (p=0.087). Bone age SDS increased from 9.2±6.3 at the start of gluten free diet to 10.3±6.7 after 12 months later. Height velocity increased from 4.7±0.7 cm/year in the year before treatment to 5.1+1.2 cm/year during treatment (p=0.05). The increase in Haemoglobin, serum calcium, and serum iron was statistically significant (p<0.05).


Conclusion. Patients with celiac disease associated with type 1 diabetes mellitus frequently have poor glycemic control and impairment in several growth parameters. When these patients are put on a gluten restricted diet, they show signs of improvement in terms of weight gain, height, serum Ca, serum iron, haemoglobin, and in height velocity.


 

To study the impact of a gluten-free diet on several growth parameters in children with type 1 diabetes mellitus and celiac disease.

Publication Type
Journal
Publication Sub Type
Journal Article, Original
Title
Journal of the ASEAN Federation of Endocrine Societies
Frequency
Semi-Annual
Publication Date
May 2016
Volume
31
Issue
1
Page(s)
5-9

Objectives

To study the impact of a gluten-free diet on several growth parameters in children with type 1 diabetes mellitus and celiac disease.

LocationLocation CodeAvailable FormatAvailability
http://www.asean-endocrinejournal.org (632) 6373162 Fulltext External Link (View)
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