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Submitted: 05 December 2014 Modified: 23 September 2015
HERDIN Record #: R07-CVHRDC-14120501460968

A follow-up study on the efficacy in terms of symptomatic relief of rabeprazole in patients diagnosed to have laryngopharyngeal reflux by reflux symptom index and reflux finding score

Benedict  R. Go

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Setting: The study was conducted at Room 1 (Family Medicine Department) at the Out-Patient Department of the Vicente Sotto Memorial Medical Center, B. Rodriguez St., Cebu City, Philippines.


Study Population: The participants of the study were compromised of patients aged 15 and above diagnosed with LPR via the RSI and RSF seen from April to December 29, 2005.


Intervention: The data were collected using the data collection form which contained personal information, pertinent history, vital signs as well as the RSI and RFS tables. Consent forms were signed by each participant. They were prescribed Rabeprazole 10 mg tablets to be taken twice a day, 30 minutes before meals for a period of 4 weeks. Weekly follow-ups were done to reassess RSI, while RFS was reassessed in each patient after the 4 week  treatment period.


Results: There were a total of 47 patients enrolled in the study. Based on RSI, after 4 weeks of treatment with Rabeprazole, there was an average  reduction of symptoms of about 80%. Complete resolution was seen in 16% of patients. The RFS did not show significant changes in laryngeal findings after 4 weeks of treatment.


Conclusion: The patients that were diagnosed and treated with were aged 20 to 59 years old but mostly from the age group 30 to 39 years old. Almost 2/3 were female and about 3/4 were married. About 2/5 of them were unemployed, dependents of housewives. Half of the patients were either drivers, security guards, sales clerks, factory workers and food servers. Most patients however experienced significant relief of symptoms even after the first week of treatment. This can be attributed to the efficient acid suppression of the above mentioned PPI. Laryngeal healing would take longer than 4 weeks even without further acid reflux from the stomach.


 

Publication Type
Research Report
Date
April 1-December 29, 2005

Objectives

A. General Objective:


To identify patients with Laryngopharyngeal Reflux using the Reflux Symptom Index and Reflux Finding Score seen at the Family Medicine Section of the Out-Patient Department of the Vicente Sotto Memorial Medical Center form April to December 2005 and to determine the efficacy of Rapebrazole in terms of symptomatic relief using the same parameters in these patients.


B. Specific Objectives:


    a. To identify the common symptoms presented by patients with LPR


    b. To know how many patients are diagnosed to have LPR at the family Medical Section of the OPD of VSMMC from April to December 2005.


    c. To know the demographic profile of patients with LPR as to age, sex, marital status, smoking history, and occupation.


    d. To know the percent reduction of symptoms using RSF and RSI after 1,2,3, and 4 weeks with treatment of Rapebrazole.

LocationLocation CodeAvailable FormatAvailability
Vicente Sotto Memorial Medical Center Fulltext Print Format
1. Hernandez, M. . Clinical Practice Guidelines for LPR.. Symposium on Laryngology: Managing Laryngoesophageal Reflux Disease. 2004.
2. Koufman, J.A et al. . "Laryngeal Reflux: Position statement of the Committee on Speech, Voice and Swallowing Disorders of the American Academy of Otolaryngology-Head and Neck Surgery. " Otolaryngology Head Neck Surgery 127, 32-35, 2002
3. Koufman, J.A , AMin, M.R , Panetti, M. . "Prevalence of Reflux in 113 Consecutive Patients with Laryngeal and Voice Disorder" Otolaryngology-Head and Neck Surgery 123(4): 385-388, 2000
4. Jeegar, Jailwala, M.D . (2003, November 30). Reflux Laryngitis. Medline Database.
5. Yorulmax, I. , Ozlugedik, S. , Kucuk, B. . "Gastroesophageal Reflux Disease: Symptoms versus pH Monitoring Results." Otolaryngology-Head adn Neck Surgery 129(5): 582-586, 2003
6. Ytitalo , J.A , Ramel, S , Hammarlurd , B , Lindgren, E . "Prevalence of Extraesophageal Reflux in Patients with Symptoms of Gastroesophageal Reflus." Gastroenterology 122:W1162:, A-587, 2002
7. Tutuian, R , Castell, D . "Diagnosis of Laryngopharyngeal Reflux." Current Opinion in Otolaryngology and Head and Neck Surgery 12, 174-179, 2004
8. Lenderking , W.R , Hilson, E. , Crawkey, J.A , Moore, D , Berzon, R , Pashos, C.L . "The Clinical Characteristics and Impact of Laryngopharyngeal Reflux Disease on Health-Related Quality of Life." Vlaue in Health 6(5): 560-565, 2003
9. Thjodleiffson, B. . "Review of Rapebrazole (Patient) in the treatment of GERD" Expert Opinion on Pharmacotheraphy 5(1): 137-149, 2004
10. Moori, M , Hammatani, K , Tagekushi, N . "The proton pump inhibitor, E3810, binds to the N-terminal half of the alpha-subunit of gastric H+, K+-ATPase." Biochem Pharmacol 49(12): 1729-1734, 1995

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