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Submitted: 20 March 2014 Modified: 04 May 2017
HERDIN Record #: NCR-TMC-14032016580362

Effect of once weekly versus daily Iron Supplementation on the Hematologic status of children with Iron-Deficiency Anemia: A Meta-Analysis.

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OBJECTIVE: To evaluate the effect of once weekly versus daily iron supplementation in improving hematologic status of children with iron deficiency anemia through a meta-analysis of randomized controlled trials. SEARCH METHODS: Both electronic and manual means were employed to search for trials irrespective of language or publication status. Highly sensitive search terms used were "randomized controlled trials", weekly iron supplementation", "daily iron supplementation" and "iron deficiency anemia". SELECTION CRITERIA: Randomized controlled trials comparing the effects of weekly and daily iron therapy in improving hemoglobin, hematocrit and serum ferritin levels of anemic children were reviewed. DATA COLLECTION AND ANALYSIS: Three reviewers independently appraised methodologic quality and extracted data. Analysis was implemented with the Review Manager version 5.0 using weighted mean difference as the treatment effect measure. All outcome variables were analyzed for evidence of heterogeneity. RESULTS: The search yielded 97 articles, of which 5 were finally selected. A total of 385 anemic children from developing countries were given weekly and daily iron supplementation for 2 to 6 months. Results of individual journals reported significant increase in levels of hemoglobin, hematocrit and serum ferritin level pre- and post supplementation. Anemia was corrected in all patients irrespective of whether they receive daily or weekly iron therapy. A significant difference was observed favouring daily supplementation in increasing hemoglobin values (MD 3.69, 95% CI 2.39 to 4.98) of all 385 subjects. Whereas no statistical difference was found between both groups with regards to raising hematocrit (MD 0.02, 95% CI -1.78 to 1.83) and serum ferritin (MD 3.15, 95% CI -6.43 to 12.74) levels of 135 and 84 subjects respectively. CONCLUSION: weekly iron supplementation is comparable to the standard daily regimen in improving hemoglobin, hematocrit and serum ferritin levels of anemic children.

Publication Type
Research Report
Date
March 20, 2009-March 20, 2014

Objectives

To evaluate the effect of once weekly versus daily iron supplementation in improving hematologic status of children with iron deficiency anemia through a meta-analysis of randomized controlled trials.

LocationLocation CodeAvailable FormatAvailability
The Medical City - Research Office Fulltext Print Format
1. Berger, J , Aguayo, V W, Tellez, W , Lujan, C , Traissac, P , San Miguel, J L. "Weekly iron supplementation is as effective as 5 day per week iron supplementation in Bolivian school children living at high altitude" European Journal of Clinical Nutrition 51(6): 381-6, . Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/9192196
2. Fraqih, A M, Kakish, S B, Izzat, M . "Effectiveness of intermittent iron treatment of two- to six-year-old Jordanian children with iron-deficiency anemia" Food and Nutrition Bulletin 27(3): 220-7, . Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/17542112
3. Hernandez, M E, Tipana-Tupas, M A, Alba, V A, Aguirre, C A. The effect of daily versus weekly iron supplementation on the hemoglobin and hematocrit of children aged 6-12 years old.. Philippines: The Medical City, 2007.
4. Nguyen, X N, Berger, J , Quyen, D T, Nguyen, C K, Traissac, P , Khoi, H H. "Efficacy of daily and weekly iron supplementation for the control of iron deficiency anaemia in infants in rural Vietnam" Sante 12(1): 31-7, . Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/11943636
5. Siddiqui, I A, Rahman, M A, Jaleel, A . "Efficacy of Daily vs. Weekly Supplementation of Iron in Schoolchildren with Low Iron Status" Journal of Tropical Pediatrics 50(5): 276-8, . Retrieved from: http://tropej.oxfordjournals.org/content/50/5/276.short
6. Viteri, F , Herceberg, S , Galan, P . Absorption of Iron supplements administered daily or weekly. A collaborative study. Nestle Foundation Annual Report Switzerland: Nestle Foundation, 1993. 83-96. . Retrieved from: http://www.idpas.org/pdf/006AbsorptionofIronSupps.pdf
7. Wharton, B A. "Iron deficiency in children: detection and prevention" British Journal of Haematology 106(2): 270-80, . Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/10460583

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