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Submitted: 14 October 2013 Modified: 05 February 2018
HERDIN Record #: PCHRD13101413221338

A biochemical assessment of the anti-inflammation activity of compounds from Philippine Medicinal plants.

Kevin D. Croft

The prostaglandins (PG's), leukotrienes (LT's) and platelet activating factor (PAF) are potent inflammatory mediators. The PG's and LT's are derived from the oxidative metabolism of arachidonic acid via the cyclooxygenase and lipoxygenase pathways, respectively. Anti-inflammatory agents prevent the formation of these mediators. The selective inhibition of the cyclooxygenase pathway by the non-steroidal anti-inflammatory drug (NSAID's) explain the anti-inflammatory action. The biochemical assessment of compounds for anti-inflammatory activity is based on the ability of very small amount of pure compounds to inhibit the formation of the inflammatory mediators in isolated Ca- ionosphere stimulated rat peritoneal leukocytes. Of the eight pure compounds tested, scandenolide, a sesquiterpene lactone from Mikania cordata (Burm.f.) BL Robinson , showed potential anti-inflammatory activity.

Publication Type
Journal
Publication Sub Type
Journal Article, Original
Title
Acta Manilana
Frequency
Annual
Publication Date
1998
Volume
37
Page(s)
65-70
LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Library Box No. 109 Fulltext pdf (Request Document)
Philippine Council for Health Research and Development Fulltext Print Format (Request Document)
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