Report an error   
Submitted: 01 April 2013 Modified: 01 April 2013

Herdin Record #: PCHRD13040116473363

Risk evaluation of alternanthera sessilis (L.) r. br. (family amaranthaceae).

Researchers

NameRole
1Erna C. Arollado Author

Publication Information

1.
Publication Type:
Journal
Publication Sub Type:
Journal Article, Original
Title:
The University of the Philippines Manila Journal
Frequency:
Semi-Annual
Publication Date:
July-December 2011
Volume:
14
Page(s):
45-52
Publisher:
University of the Philippines - Manila

Abstract

Alternanthera sessilis (L.) R. Br. (Amaranthaceae) locally known as lupo in Panay Island is popularly used by local folks who have complaint of symptoms of anemia. This therapeutic claim has been handed down from generation to generation yet, there is no report conducted on its non-toxic effect. Thus, evaluation on its safety was performed in mice and rats. The parameters used were median lethal dose (LD) and liver enzymes tests such as aspartate aminotransferase (AST) and alanine aminotransferase (ALT). The result of LD determination showed that neither of the test animal died nor manifested any sign of toxic effect even after a dose of 10,000 mg/kg body weight was given. The data generated from the liver enzymes test manifested normal values after 15 days of treatment.

Results of the tests analyzed using statistical package for the Social Sciences (SPSS) 15 showed no significant difference on the test drug in experimental animals

Thus, the present study suggests that lupo is safe or non-toxic.


Physical Location

LocationCall NumberAvailable FormatAvailability
Philippine Council for Health Research and Development Library Box No. 16 Fulltext Print Format (Request Document)

References

1. Abulude, F O. "Nutritional evaluation of aquatic weeds in Nigeria. Retrieved July 2006 from the worldwide Web://ejeafche.uvigo.es/4(1)2005/003412005F.htm" Electronic Journal of Environmental, Agriculture and Food chemistry 4(1): 835-840, 2005
2. Beynen, A C, Meijer, G W, Van der Meer, R . "Comparison of rats with mice concerning the response of lipid metabolism to dietary fats" Zeitschrift fur Ernahrungswissenschaft 27(3): 1988
3. Biosystems, S A. "Costa Brava 30 Barcelona (Spain)" ,
4. Diel, K H, Hull, R , Morton, D , Ptisfer, R , Rabemapianina, Y , Smith, D , Vidal, J M, Van de Vorstenbosch, C . "A good practice guide to the administration of substances and removal of blood, including routes and volumes" J Appl Toxicol 21, 15-23,
5. Guevarra, B Q. "A guidebook to plant screening: Phytochemical and biological. Manila, Philippines: University of Santo Tomas Publishing House" , 101-105,
6. Lin, Song-Chow , Lin, Y , Shyuu, S , Lin, C . "Hepatoprotective effects of Taiwan Folk Medicine: Alternanthera sessilis on liver damage induced by hepatotoxins" Phytotherapy Research 8, 391-398, 1994
7. Ogle, B , Tuyet, M , Duyet, H , Dung, N . "Food, feed or medicine: The multiple functions of edible wild plants in Vietnam" Economic Botany 57(1): 103-117, 2003
8. Quisumbing, E . "Medicinal Plants of the Philippines, Katha Publishing Inc, Quezon City Philippines" , 1978
9. Rigamonti, C , Andorno, S , Maduli, E , Capelli, F , Boldorini, R , Sartori, M . "Gender and liver fibrosis in chronic hepatitis: the role of iron status. Alimentary Pharmacology and Therapeutics. Published online" 21(12): 1445-1451, June 2005
10. Shiratani, H , Katoh, M , Nakajima, M , Yokoi, T . "Species differences in UDP-Glucuronosyltransferase activities in mice and rats" Drug Metabolism and Disposition 36(9): 1745-1752, 2008
11. Valle, A , Silvestri, E , Moreno, M , Chambery, A , Oliver, J , Roca, P , Goglia, F . "Comparative pharmacologyof the novel cyclopropylpyrroloindole-prodrug carzelesin in mice, rats and humans" Cancer Research 58, 2410-2416, June 1998
12. "World Health Organization. The International Program on Chemical Safety (IPCS). The WHO recommended classification of pesticides by hazard and guidelines to classification Geneva, Switzerland" , 2004