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Submitted: 04 January 2012 Modified: 03 May 2013
HERDIN Record #: NCR-JRRMMC-01041203012655

Effectivity of topically applied 0.1% Tretinoin in the treatment of Molluscum contagiosa

Abstract

CONTEXT:
Therapeutic options for molluscum contagiosum rely primarily on destructive measures such as surgery and electrocautery. Curettage and cryotherapy are fairly effective, but the pain and emotional trauma associated with these procedures make them undesirable for use in the pediatric population.

OBJECTIVE:
To determine the efficacy, safety and acceptability of topical application of 0.1% tretinoin cream in the treatment of molluscum contagiosum.

STUDY DESIGN: Open clinical trial

STUDY SETTING: Tertiary Government Hospital (Jose R. Reyes Memorial Medical Center)

STUDY POPULATION: Thirty-two (32) patients with molluscum contagiosa

MANEUVERS:
The patients were given 0.1% Tretinoin cream (Stieva A) applied twice a day to molluscum contagiosa lesions for a period of four weeks or until clinical remission.

OUTCOME MEASURES:
Complete or no resolution of molluscum contagiosa lesions.

RESULTS:
Out of 32 patients who enrolled in this study, only 11 patients completed the clinical trial. There was negative cure in the eleven patients. All of them developed retinoid dermatitis. Patients were not satisfied with the treatment trial.

CONCLUSION:
0.1% Tretinoin cream is fairly tolerable but not effective nor acceptable for the treatment of molluscum contagiosum.

1.
Publication Type:
Research Report
Date:

Objectives

General Objective:
To determine the efficacy, safety and acceptability of topical application of 0.1% tretinoin cream in the treatment of molluscum contagiosum.

LocationCall NumberAvailable FormatAvailability
Medical Library, 5/F Training and Research Office, Jose R. Reyes Memorial Medical Center 01-1 #20 Abstract Print Format