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Submitted: 09 September 2011 Modified: 19 November 2012
HERDIN Record #: NCR-JRRMMC-09091104090177

Effect of paracetamol versus diclofenanc Na to morphine after hysterectomy.

Silvino Jr Clemente,
Ulga Luisa V. Casino,

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We have evaluated the analgesia efficacy of IV paracetamol and diclofenac sodium during the first 16 hours after abdominal hysterectomy in a placebo controlled double-blind study. We studied 30 patients receiving intrathecal morphine after a standardized anesthetic, allocated randomly to receive IV paracetamol 500 mg, diclofenac 75mg and placebo after wound closure and at 8 and 16 hours. Mean and standard deviation were used to describe the data. Kruskal-Wallis Test and Mann-Whitney tests (non-parametric tests) for ordinal data were used to compare pain scores. A 95% confidence level was considered significant (p<0.05). All subjects included in the study underwent abdominal hysterectomy (TAHBSO), for myoma uteri. Mean age of patients for each group did not differ significantly. Proportion of subjects reporting scores of 3 and below at 16th hour was significantly different among the three groups - 100% of subjects in the paracetamol group, 40% in the diclofenac group and none in the placebo group.

Publication Type
Research Report
Date

Objectives

General:
To compare the magnitude of the synergistic effect of parenteral paracetamol and diclofenac sodium (NSAID) to morphine in post operative pain management of patients who underwent hysterectomy.

Specific:
1. To establish the synergistic effects of paracetamol in augmenting the action of morphine during hysterectomy.
2. To establish the synergistic effects of diclofenac sodium in augmenting the action of morphine during hysterectomy.
3. To compare the morphine doses postoperatively from patients receiving paracetamol and diclofenac sodium.
4. To compare the pain VAS postoperatively from patients receiving paracetamol and diclofenac sodium.

LocationLocation CodeAvailable FormatAvailability
Medical Library, 5/F Training and Research Office, Jose R. Reyes Memorial Medical Center 2010-01 #16 Abstract Print Format

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