Report an error   


Submitted: 23 October 2012
HERDIN Record #: R04A-DLSHSI-12102309283866

Pre-emptive analgesia to an exercise- induced muscular pain .

See More

BACKGROUND: Physical fitness nowadays cannot easily be maintained particularly when one does not have the luxury of time to do physical exercise because of the demand of individual's work. The pain concern of every individual related to physical exercise limits them more to maintain fitness. A double-blind randomized crossover trial was utilized in this study. The efficacy of Celecoxib 400mg as pre-emptive analgesia to an exercise-induced pain was tested. The study showed that there was a pattern when a Celecoxib 400mg was taken four hours prior to exercise. Pain was minimized and this was evident in an hour after exercise even if the statistical result was not significant. However, the data presented could not totally conclude that Celecoxib 400mg taken before exercise had no role in alleviating exercise-induced pain because of the large variation presented in this study.
---
OBJECTIVES: General - To investigate the efficacy of a pre-emptive analgesia in minimizing exercise-induced muscular pain. Specific - To evaluate the efficacy of Celecoxib use as a pre-emptive analgesia for exercise-induced muscular pain measured immediately after, one, eight and twenty-four hours post-exercise.
---
DESIGN: The study design was double blind randomized crossover trial.
---
PARTICIPANTS: The participants were ten healthy young adults (18-28 year-old male), non-athlete/non-weight trained. Procedures, risks and benefits of the study were explained. Informed written consent was obtained from each subject.
---
CONCLUSION: The study showed that a pattern was observed when Celecoxib 400mg was taken four hours prior to exercise reducing pain which was evident in an hour after exercise. The result of this study was not statistically significant. However, the data presented could not totally conclude that Celecoxib 400mg taken before exercise has no role in alleviating exercise-induced pain because of the large variation presented in this study.
---
RECOMMENDATIONS: With the knowledge of COX-2 being inducible and its specific inhibitor's effects on pain mirrored its effect on inflammation, a recommendation to standardize the exercise load to a higher weight, intensity and/or frequency could help enhance pain generation. Homogenous stress load on the exercised extremity should also be applied everytime the subject records his pain score. Based on statistical computation and strength of the study design, the study samples appear to be representative of the general population. Perhaps a study of a larger scale could be conducted to further eliminate the large variance. Female participants and age range of the subjects could be increased to add more samples. Furthermore, the pain threshold difference of each participant should be addressed by setting a standard measurement to assess an individual's pain limit so that there will be a baseline for each subject. Use of other measurement device could also be utilized aside from VAS.

Objectives

General Objective
To investigate the efficacy of a pre-emptive analgesia in minimizing exercise-induced muscular pain.
---
Specific Objective
To evaluate the efficacy of Celecoxib use as a pre-emptive analgesia for exercise-induced muscular pain measured immediately after, one, eight and twenty-four hours post-exercise.

Copyright © One Window Project 2018. All rights reserved.