Report an error   
Submitted: 17 December 2012 Modified: 27 June 2017

Herdin Record #: PCHRD12121721211033

Thyroid extract in the management of hypercholesterolemia.

Researchers

NameRole
1Edward  Z. Fang Author
2Crisostomo M. Serrano Author

Publication Information

1.
Publication Type:
Journal
Publication Sub Type:
Journal Article, Original
Title:
Acta Medica Philippina
Frequency:
Quarterly
Publication Date:
January-March 1960
Volume:
16
Issue:
3
Page(s):
143-155
Publisher:
College of Medicine and Institute of Public Health, University of the Philippines - Manila

Abstract

Fourteen cases with hypercholesterolemia of various etiologies were treated with thyroid extract at the dosage of 2-6 grains daily for periods varying from 4 weeks to 16 months. Lowering of the serum cholesterol was noted in all cases. Elevation of the same was noted after the suspension of the therapy. There were no side effects noted. These observations are in consonance with those of the foreign workers.
Four patients with arteriosclerotic heart disease improved clinically with the therapy. It is the opinion of the author that it throughout the therapy. It is the opinion of the author that it is safe to use thyroid extract to reduce serum cholesterol in patients with coronary heart disease.


Physical Location

LocationCall NumberAvailable FormatAvailability
Philippine Council for Health Research and Development Library Fulltext Print Format (Request Document)

References

1. Genes, J.L. et al. "Review of a short term protocol about a Hypocholesterolemiant Pharmacologic Action" La presse Medicale 66, 1108-1110, June 1958
2. Carcy, M. . "Results obtained with a new Cholesterolytic Drug" Tolouse Medical 58, 785-803, October 1957
3. Amselem, A. . "Contribution to the Study of Experimental Atheroma" Thesis in Pharmacy, Toulouse , 1959
4. Castaigne, A. . "A study about the Repartition of both the Free and Easterified Fractions of Cholesterolbetween the Apha- and Beta- Lipoproteins" Annales de Biologic Clinique 15, 56, 1956
5. Berthier, G. . "Medical Treatment of Atherosclerosis" Gazette Medicale de France 65(19): 1557-1559, October 1958
6. Wood, J.D. et al. "Fatty Acid Inhibition of Cholesterol Synthesis" Canada Journal of Biochemistry and Physiology 34, 861, 1956
7. Menn, G.V. . "Essential Fatty acids and Atherosclerosis: A Critique of the Present Knowledge" AMA Arch Int Med 100, 77, 1957
8. Curran, G.L. . "Inhibiton of Cholesterol biosynthesis in Man" AMA Arch Int Med 101(4): 685-689, April 1958
9. Achor, R.W.P. et al. "Treatment of Hypercholesterolemia with Nicotinic Acid" Collected papers of the Mayo Clinic and the Mayo Foundation 49, 411-413, 1957
10. Goolden, A.W.G. . "The Physiological Activity of Tetra-iodo-Thyroacetic Acid" Lancet 1, 885-889, June 1956
11. Trotter, W.R. . "Effect of Tri-iodothyroacetic acid on Cholesterol Levels" Lancet 1, 885-889, June 1956
12. Oliver, M.F. et al. "The influence of Tri-iodo-Thyroacetic acid on the Circulating Lipids and ipoproteins in Euthyroid Men with Coronary Heart Disease." Lancet 1, 124-125, January 1957
13. Strisower, B. et al. "Long term Effect of Dried Thyroid on Serum Lipoprotein and Serum Cholesterol Levels" Lancet 1, 120-123, January 1957
14. Starr, Paul et al. "Reduction of Serum Cholesterol by Sodium-Dex-tro-Thyroxine" AMA Arch Int Med 105, 830-842, June 1960
15. Fang, E.Z. and, Reyes, J. Jr. . "Thyroid Extract in the Management of Hypertension" Acta Medica Philippina 10(1): 311-336,