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Submitted: 07 June 2012 Modified: 27 June 2017
HERDIN Record #: PCHRD12060715222822

The unique phenomenology of sex-linked dystonia parkinsonism (XDP, DYT3, "Lubag") .

1Lillian  V. Lee,
2Corazon  Rivera,
3Rosalia A. Teleg,
4Marita B. Dantes,
5Paul Matthew D. Pasco,
6Jose  Arancillo,
7Rodelyn  . Villareal-Jordan,
8Roland Dominic G. Jamora,
9Cynthia  Demaisip,
10Elma  Maranon,
11Olivia  Peralta,
12Ruth  Borres,
13Raymond L. Rosales,
14Cirnueb Tolentino,
15Mercy Joyce  Monding,
16Sonia  Sarcia
Child Neuroscience Center - Philippine Children's Medical Center,
Philippine Movement Disorder Surgery Center - Cardinal Santos Medical Center,
Department of Neurosciences, College of Medicine - Philippine General Hospital - University of the Philippines-Manila,
Movement Disorders Center and Section of Neurology, International Institute for Neurosciences - St. Luke's Medical Center,
Roxas City Health Office, Roxas City,
Department of Neurology and Psychiatry - Santo Tomas University Hospital,
St. Paul's Hospital, Iloilo City

Abstract

Sex-linked dystonia parkinsonism (XDP, DYT3, "Lubag") is an adult-onset, progressive, debilitating movement disorder first described in Filipino males from Panay Island in 1975. XDP manifests predominantly as torsion dystonia, later combined with or sometimes replaced with parkinsonism. Within the Island of Panay, the preva-lence rate is highest in the province of Capiz, where 1:4000 men suffer from the disorder. There is a high degree of penetrance and generalization. While women often serve as carriers, XDP is not limited to men. An updated XDP Philippine registry (as of January 2010) has identified 505 cases, with 500 males and 5 females. While some report that females may carry a milder form of the disorder, in our experience, both sexes generally follow a similar progressive clinical course.

1.
Publication Type:
Journal
Publication Sub Type:
Journal Article, Original
Title:
International Journal of Neuroscience
Frequency:
Unknown
Publication Date:
2011
Volume:
121
Issue:
S1
Page(s):
3-11
Publisher:
Information Health Care

2.
Publication Type:
Journal
Publication Sub Type:
Journal Article, Original
Title:
The Philippine Journal of Neurology
Frequency:
Semi-Annual
Publication Date:
August 2012
Volume:
16
Issue:
1
Page(s):
63-71
Publisher:
Philippine Neurological Association

LocationCall NumberAvailable FormatAvailability
U.S. National Library of Medicine: PubMed/Medline Abstract External Link (View)
U.S. National Library of Medicine: PubMed/Medline Fulltext pdf (Request Document)
Philippine Council for Health Research and Development Library Box no.54 Fulltext Print Format (Request Document)