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Submitted: 07 June 2012 Modified: 27 June 2017
HERDIN Record #: PCHRD12060715222822

The unique phenomenology of sex-linked dystonia parkinsonism (XDP, DYT3, "Lubag") .

Lillian  V. Lee,
Corazon  Rivera,
Rosalia A. Teleg,
Marita B. Dantes,
Paul Matthew D. Pasco,
Jose  Arancillo,
Roland Dominic G. Jamora,
Rodelyn  . Villareal-Jordan,
Cynthia  Demaisip,
Elma  Maranon,
Olivia  Peralta,
Raymond L. Rosales,
Ruth  Borres,
Cirnueb Tolentino,
Mercy Joyce  Monding,
Sonia  Sarcia

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Sex-linked dystonia parkinsonism (XDP, DYT3, "Lubag") is an adult-onset, progressive, debilitating movement disorder first described in Filipino males from Panay Island in 1975. XDP manifests predominantly as torsion dystonia, later combined with or sometimes replaced with parkinsonism. Within the Island of Panay, the preva-lence rate is highest in the province of Capiz, where 1:4000 men suffer from the disorder. There is a high degree of penetrance and generalization. While women often serve as carriers, XDP is not limited to men. An updated XDP Philippine registry (as of January 2010) has identified 505 cases, with 500 males and 5 females. While some report that females may carry a milder form of the disorder, in our experience, both sexes generally follow a similar progressive clinical course.

Publication Type
Journal
Publication Sub Type
Journal Article, Original
Title
International Journal of Neuroscience
Frequency
Unknown
Publication Date
2011
Volume
121
Issue
S1
Page(s)
3-11

Publication Type
Journal
Publication Sub Type
Journal Article, Original
Title
The Philippine Journal of Neurology
Frequency
Semi-Annual
Publication Date
August 2012
Volume
16
Issue
1
Page(s)
63-71
LocationLocation CodeAvailable FormatAvailability
U.S. National Library of Medicine: PubMed/Medline Abstract External Link (View)
U.S. National Library of Medicine: PubMed/Medline Fulltext pdf (Request Document)
Philippine Council for Health Research and Development Library Box no.54 Fulltext Print Format (Request Document)

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