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Submitted: 26 January 2012 Modified: 16 August 2016
HERDIN Record #: PCHRD12012609311685

A randomized double-blind comparison of spinal levobupivacaine 0.5% versus pH-adjusted levobupivacaine 0.5% solution on onset of motor blockade.

Miguel Angelo Tamayo,
Jose Rowell Ramirez

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Levobupivacaine is the oure S(-)-enantiomer of racemic bupivaciane but is less toxic to the heart and central nervous system. Previous studies have shown that it is of equal potency with Bupivacaine in terms of onset of motor blockade, duration of sensor and motor blockade but a significant delay in the onset motor blackade (21 min versus 10 min). one study was done where aspirated CSF was used instead of adding sodium bicarbonate to adjust the pH-adjusted Levobupivacaine0.5% for spinal anesthesia. Thirty patients undergoing elective minor surgery received either 15mg of Levobupivacaine 0.5% isobaric or solution of 15mg of Levobupivacaine 0.5% isobaric with 1:1 mixture of aspirated CSF. Time of motor block onset and pH level were measured in both groups. Results showed faster motor block onset for pH-adjusted Levobupivacaine (1.87 +/- 0.65min versus 18.70 +/-3.26min) and pH level was also higher (7.12 +/-0.05 versus 6.04 +/-0.28). we conclude that the alkalinization by addition of CSF to Levobupivacaine 0.5% via 1:1 mixture speeds the onset motor block. Time to reach a Bromage score from 0 to 3 was shorter and pH level was more basic from the pH-adjusted Levobupivacaine, which may explain the faster onset since pH of the solution was closer to the pKa of Levobupivacaine.

Publication Type
Publication Sub Type
Journal Article, Original
Philippine Journal of Anesthesiology
Publication Date
July-December 2008
LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Library Box No. 115 Fulltext pdf (Request Document)
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