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Submitted: 16 May 2007 Modified: 06 September 2019
HERDIN Record #: PCHRDPC060003

Burkholderia cepacia outbreak in the pediatrics wards of the Philippine General Hospital.

 Diola, Jocyl B,
 Maramba-Untalan, Cec

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OBJECTIVE: To describe an outbreak which occurred at the Pediatric Wards of the Philippine General Hospital

METHODS: A cross-sectional study was conducted at the Pediatric Wards of the Philippine General Hospital. Bacteriology records of all pediatric patients from August 2001 to October 2001 were reviewed for identification of all blood isolates of Burkholderia cepacia and medical records of those who were positive for the organism were likewise reviewed.

RESULTS AND CONCLUSION: Thirty-five patients from the Pediatric Wards of the Philippine General Hospital grew Burkholderia cepacia in their blood from August to October 2001. Ages of cases ranged from 3 days old to 17 years old. Sepsis (74.3 percent) was the most common clinical presentation, followed by pneumonia (17.1 percent). Conditions found to be associated with Burkholderia cepacia infection were prolonged hospitalization (85.7 percent), malnutrition (37.1 percent) malignancy (28.6 percent), and invasive procedures (25.7 percent). Most of the isolates were sensitive were Metopenem (100 percent), Imipenem (100 percent), Cefepime (100 percent), Piperacillin-Tazobactam (100 percent), Ciprofloxacin (100 percent), and Ceftazidime (97 percent). The isolates were highly resistant to Aminoglycosides, Aztreonam, and Ceftriaxone. Fifty (50 percent) of patients given Ceftazidime and Piperacillin-Tazobactam did not show improvement and were shifted to other antibiotics. The outcome of patients were generally favorable. Eighty percent of patients were discharged cured, 14.3 percent expired due to their illness, while 5.7 percent were lost to follow-up The source of Burkholderia Cepacia involved in this outbreak remains unknown. Water analysis as well as bacterial cultures of antiseptics used all turned out to be negative. A droplet route of transmission is also unlikely because the patients involved in this outbreak were situated beds apart from each other. The outbreak just resolved spontaneously Cefepime as monotherapy was recommended for the treatment of this infection. The importance of rational antibiotic use and strict hand should be emphasized. (Author)

Publication Type
Publication Sub Type
Pediatric Infectious Disease Society of the Philippines Journal
Publication Date
January-December 2003
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