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Submitted: 16 May 2007 Modified: 26 April 2016
HERDIN Record #: PCHRDPC051106

Postoperative analgesic effects of a placebo controlled trial of intraarticular morphine sulfate and intraarticular pethidine HCI for patients undergoing anterior cruciate ligament reconstruction using bone patellar graft.

1Alet Gerardo C. Hernandez,
2Jonathan  G. Dela Cruz,
3Jonnel L. Lim
Department of Anesthesiology - St. Luke's Medical Center

Abstract

Background: Postoperative pain is considered the main cause of morbidity after anterior cruciate ligament (ACL) repair Objectives: This study was designed to determine whether a placebo controlled trial of intraarticular (IA) Morphine sulfate and IA Pethidine HCI would provide postoperative pain relief for patients undergoing ACL reconstruction utilizing bone patellar graft Methods: A randomized, double blind, placebo controlled trial of 60 patients, 18-65 years, ASA I and II scheduled for ACL reconstruction were included in the study. Group I received IA Morphine sulfate 3mg (0.015 percent) solution, Group II received IA Pethidine HCI 30mg (0.15 percent) solution and Group III received IA saline 20 cc solution alone. VAS scores were obtained during the 1st, 2nd, 6th and 24th hour after surgery. Analgesic duration, rescue medication consumption, and occurrence of complications were determined Results: VAS score comparisons were analyzed using Kruskal-Wallis Test and Wilcoxons Matched Pairs Signed Rank test which revealed significant differences among all groups. Analgesic duration and 24-hr rescue medication consumption were also analyzed and results also demonstrated significant differences. However, occurrence of complications was not observed in all clinical trial groups Conclusion: We conclude that IA morphine and IA Pethidine HCI have analgesic effects. IA Pethidine HCI has less analgesic effects as compared to IA morphine sulfate. IA morphine sulfate has the longest analgesic duration and lastly, that IA Morphine sulfate and IA Pethidine HCI offer a well tolerated postoperative pain control with no evidence of complications. (Author)

1.
Publication Type:
Journal
Publication Sub Type:
Journal Article, Original
Title:
Philippine Journal of Anesthesiology
Frequency:
Semi-Annual
Publication Date:
July-December 2004
Volume:
16
Issue:
1
Page(s):
31-37
Publisher:
The Philippine Society of Anesthesiologists, Inc.

Objectives

This study was designed to determine whether intraarticular (IA) Morphine Sulfate, IA Pethidine HCI, placebo would provide postoperative pain relief for patients undergoing ACL reconstruction utilizing bone patellar graft. Specific objective of the study were to: (1) Determine if IA Pethidine HCI has the same analgesic effect with IA Morphine sulfate thru visual analog scale (VAS) comparison, (2) Determine analgesic duration for all groups, (3) Compare rescue medication by documenting IV/ Oral NSAID and IV opioid consumption, and (4) Determine occurrence of postoperative complication like nausea, vomiting, pruritus and respiratory depression.

LocationCall NumberAvailable FormatAvailability
Philippine Council for Health Research and Development Library Box No. 115 Fulltext pdf (Request Document)
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