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Submitted: 13 April 2009 Modified: 13 February 2014
HERDIN Record #: PCHRD041309110413

Lack of efficacy of high dose intravenous immunoglobulin treatment of severe thrombocytopenia in patients with secondary dengue virus infection.

1Efren M. Dimaano,
2Kazunori Oishi,
3Edna A. Miranda,
4Atsushi Kumaori,
5Mariko Saito,
6Myrna D. Valerio,
7Shingo Inove,
8Ronald Matias,
9Cynthia A. Mapua,
10Maria T. Alonzo,
11Shoko Honda,
12Filipinas F. Natividad
Nagasaki University, Japan,
Chiba Institute of Science,
Osaka University, Japan,
San Lazaro Hospital,

Abstract

Because most cases of secondary dengue virus infection are associated with an increased level of platelet-associated IgG, a high dose of intravenous immunoglobulin (IVIG) may have an effect on the development of severe thrombocytopenia in this disease. A randomized, controlled study was conducted with two treatment groups consisting of a treatment (IVIG) group (n = 15) and a non-treatment (non-IVIG) group (n = 16) to determine whether a high dose of IVIG is effective in hastening the recovery from thrombocytopenia in patients with secondary dengue virus infection. No significant difference was found in the baseline demographic data between the two groups. No adverse effect of IVIG was observed, but no effect in hastening the recovery of platelet counts was found in patients with secondary dengue infections. The lack of efficacy of IVIG suggests that platelet clearance by macrophages through Fc receptors is not a primary mechanism in this disease.

1.
Publication Type:
Journal
Publication Sub Type:
Journal Article, Original
Title:
St. Luke's Journal of Medicine
Frequency:
Semi-Annual
Publication Date:
January-June 2010
Volume:
6
Issue:
1
Page(s):
59-62
Publisher:
St. Luke's Medical Center

LocationCall NumberAvailable FormatAvailability
Philippine Council for Health Research and Development Library PCHRD041309110413 Abstract Print Format (Request Document)
Philippine Council for Health Research and Development Library box no. 35 Abstract pdf (Download)
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