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Submitted: 27 January 2007 Modified: 27 January 2017
HERDIN Record #: PCHRD012607080121

Medical therapy versus angioplasty in atherosclerotic renal artery stenosis: A meta-analysis of randomised controlled trials .

1Marizel G. Mallari Catungal,
2Ma Cecilia Nicolas-Vinarao,
3Julius John A. Serrano,
4Loreto J. Codamos,
5Oscar D. Naidas

Abstract

Title: Medical therapy versus Angioplasty in Atherosclerotic Renal Artery Stenosis: A meta-analysis of Randomised Controlled Trials Background: Renal artery stenosis (RAS) can cause both renovascular hypertension reversible with renal revascularization, and renal insufficiency. Treatment of RAS by surgery or balloon angioplasty aims at avoiding lifelong antihypertensive treatment and progressive renal ischemia. Objectives: A meta-analysis will be undertaken to assess the relevant literature and to establish the comparative effectiveness of percutaneous angioplasty and medical therapy in controlling hypertension and progression of renal disease in atherosclerotic RAS. Data Sources: The English-language medical literature identified by MEDLINE search, cross-references and manual search. Study Selection: All randomised controlled trials that compared percutaneous angioplasty or interventional angioplasty or interventional angioplasty with medical therapy with at least 6 months of planned follow-up on treatment of atherosclerotic RAS were selected. Studies on fibromuscular dysplasia as cause of RAS were excluded. A total of 210 patients in 3 studies were included. Data Extraction: Data on mean level of blood pressure, mean level of renal function (serum creatinine and creatinine clearance) and number of antihypertensive drugs or median number of defined daily closes were extracted. Data Synthesis: Among 210 patients included in the study, 106 were assigned in the medical group and 104 patients in the angioplasty group. There was no significant differences between medical therapy and angioplasty in terms of mean level of systolic BP (Weighted Mean Difference (WMD)-0.12[-5.1 to 4.9,95 percent Confidence Interval (Cl)]),diastolic BP (WMD- 0.35[-3.3 to 2.6,95 percent C1 ], mean level of creatinine (WMD -0.43[-0.27 to 0.18,95 percent C1] and mean level of creatinine clearance (WMD -5.8 [-5.8 to 2.04, 95 percent C1]). There is less number of anti-hypertensive drugs and median number of defined daily doses in the angioplasty group, p value

1.
Publication Type:
Journal
Title:
Philippine Journal of Nephrology
Frequency:
Semi-Annual
Publication Date:
July-December 2004
Volume:
19
Issue:
2
Page(s):
64-70
Publisher:
Philippine Society of Nephrology

Objectives

A meta-analysis will be undertaken to assess the relevant literature and to establish the comparative effectiveness of percutaneous angioplasty and medical therapy in control of hypertension and progression of renal disease among patients with atherosclerotic RAS. The review will address the following question: What is the comparative effectiveness of percutaneous angioplasty and medical therapy (INTERVENTION AND COMPARISON INTERVENTION) in the control of hypertension and progression of renal disease (OUT COME) among patients with atherosclerotic renal artery stenosis (PATIENTS)?

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Philippine Council for Health Research and Development Library Box No. 53 Fulltext pdf (Request Document)