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Submitted: 16 May 2007 Modified: 10 December 2013
HERDIN Record #: PCHRDPC961249

Halofantrine in the treatment of acute uncomplicated falciparum malaria in the Philippines.

2 Santos MN,
3 Saniel MVC,
4 Quiambao BP,
5 Bustos DG,
6 Carlos CC


In an open clinical trial, thirty patients 14 to 44 years old and with acute uncomplicated falciparum malaria were given halofantrine hydrochloride 500 mg (2 tablets) 6-hourly for 3 doses, a total dose of 1500 mg. All 30 patients were cured with a mean asexual parasite clearance in 6 patients consisting of mild to moderate headache, dizziness and abdominal muscle spasm. Drug-induced hemolysis did not occur in two G6PD deficient patients. Twenty-three out of 28 isolates tested (82%) were resistant to amodiaquine, 3(11%) were resistant to the sulfadoxine-pyrimethamine combination, and all were sensitive to chloroquine, quinine and mefloquine by in vitro microtest. The study confirms the efficacy of halofantrine hydorchloride as a blood schizonticide in falciparum malaria. (Author)

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Publication Sub Type:
Mosquito Borne Dis Bull
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Philippine Council for Health Research and Development Library Box. No. 119 / LA Abstract Print Format (Request Document)