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Submitted: 17 January 2007 Modified: 25 July 2013

Herdin Record #: PCHRD011607080100

A randomized controlled trial on the use of virgin coconut oil in augmenting weight gain among infants weighing 1500 grams or less: Preliminary results.

Researchers

NameRole
1Jacinto Blas V. Mantaring III Author
2Maribel R. Amante-Aurelio Author

Related Institutions

Institutions NameRole
University of the Philippines-Philippine General Hospital Medical Center Authors Affiliation

Publication Information

1.
Publication Type:
Journal
Publication Sub Type:
Journal Article, Original
Title:
Philippine Journal of Pediatrics
Frequency:
Quarterly
Publication Date:
October-December 2005
Volume:
54
Issue:
4
Page(s):
223-229
Publisher:
The Philippine Pediatric Society, Inc.

Objectives

The objective of this investigation is to determine if low birth weight neonates (weighing <1500 g) who are given virgin coconut oil as a supplement to their breastmilk or preterm formula will have better weight gain compared to neonates without such supplementation.
Specifically, it was done (1) to determine if there is a difference in weight gain (grams/day) of infants receiving breastmilk or preterm formula supplemented with 0.5 ml virgin nut oil per ounce of milk compared to infants receiving breastmilk or preterm formula alone; (2) to determine if there is a difference in the occurrence of vomiting, diarrhea, abdominal distension and feeding residuals in the two treatment groups; (3) to determine if there is a difference in the duration of intervention between low birth weight infants among the two treatment groups; and (4) to determine the difference in the occurrence of nosocomial infections such as sepsis, pneumonia, urinary tract infection, meningitis and necrotizing enterocolitis, and deaths between the two treatment groups.

Abstract

RATIONALE. Medium chain triglyceride (MCT) oil is used to augment weight gain of low birth weight infants. However, it is commercially unavailable. Coconut oil contains the most concentrated, natural source of MCT and lauric acid which provides antibacterial properties.
PRIMARY OBJECTIVE. To determine if neonates weighing < / - 1500 g given virgin coconut oil (VCO) will have better weight gain compared to neonates without such supplementation.
DESIGN. Triple-blind, randomized controlled trial.
SETTING. Neonatal intensive care unit of a tertiary government hospital.
PATIENTS AND METHODS. Neonates with birth weight <1500 g; able to tolerate at least 50 ml/kg/day of enteral feedings, and with informed consent were included. Subjects were randomized into either treatment or control group. Both groups received preterm formula or breastmilk. VCO was added at 0.5 ml/oz to the feedings of the treatment group. The outcomes were analyzed by intention to treat. A p-value <0.05 was considered statistically significant. The difference in weight gain, duration of intervention, the occurrence of feeding intolerance and sepsis were among those measured.
RESULTS. Ninety neonates (46 in the treatment group, 44 in the control group) were included. The baseline characteristics had no statistical difference except for birth head circumference (p=0.04) and entry mid-upper arm circumference (p=0.03) which were both higher in the treatment group. There was a trend towards higher weight gain per day (27.1 +/- 16.8 vs. 22.1 +/- 117.1, p=0.666) and other growth parameters, and shorter duration of intervention in the treatment group. There were fewer adverse events in the treatment group. Sepsis was lower in the treatment group, and this was statistically significant (p=0.008).
CONCLUSION. This interim analysis shows a trend towards an increase in weight gain and other growth parameters among those whose feedings were augmented with VCO. The occurrence of feeding intolerance and sepsis were also lower in the treatment group. To reach statistical power, the study is ongoing. (Author)


Physical Location

LocationCall NumberAvailable FormatAvailability
Philippine Council for Health Research and Development Library Box No. 66 Fulltext Print Format (Request Document)

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