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HERDIN Record #: PCHRD012108080119 Submitted: 22 January 2008

An In-vitro study of the antifungal effect of propolis extract vs ketoconazole (Nizoral)on standard candida albicans: A comparative study.

Ma. Michelle Vita,
Karen Faye Nava,
Nolan Genova,
Alfrancis UbaÃÆââ,
Noemie Manzanero,
Jose Exekiel Galvan,
Ryan Ruiz,
Roda Imperial,
Baby Lovella Bazar

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Ketoconazole (Nizoral) and propolis extract at different concentrations (25 percent, 50 percent, 75 percent) were tested and evaluated for fungal inhibitory activity against candida albicans, a saprophytic pathogen of man and animals using filter paper disc agar method where the zone of inhibition was recorded in millimeters at 24 hours, 48 hours and 75 hours.The data was analyzed using one-way of variance (ANOVA) and post Hoc Test (Bonferroni.)
Propolis extract exhibited comparable inhibitory effect of ketoconazole at 50 percent and 75 percent concentration.However,the observed inhibitory effect is comparable only until 24 hours for 50 percent propolis extract and 48 hours for 75 percent propolis extract. All treatment decreased its inhibitory effect at 72 hours.Thus another application of 50 percent and 75 percent propolis extract is hereby recommended.

Publication Type
Research Report
November 30, 2004


The main objective of the study was to determine the effectiveness of Propolis as an antifungal agent.
Specifically, the study aimed to:
1.To determine the concentration of propolis (in serial dillutions of 25 percent,50 percent and 75 percent) that would be a potent antifungal agent using the zone of inhibition.
2.To determine the efficacy of propolis after 24 hours,48 hours and 72 hours In-vitro.
3.To compare the effective concentration of propolis with commercially available antifungal agent Ketoconazole (Nizoral)

LocationLocation CodeAvailable FormatAvailability
Manila Central University-Filemon D. Tanchoco Memorial Foundation 354 Abstract

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