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Submitted: 20 September 2007 Modified: 19 January 2017
HERDIN Record #: PCHRD091907110922

Phenomenology of "lubag" or X-linked dystonia-parkinsonism.

Andrew Singleton,
Joven Cuanang,
Joel Advincula,
Katrina Gwinn-Hardy,
Paul Pasco,
Dena Hernandez,
Filipinas F. Natividad,
Virgilio Gerald H. Evidente,
Amado San Luis,
Raymund Esteban,
John Hardy,
Jhoe Anthony Alfon

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X-linked dystonia-parkinsonism (XDP), or Lubag syndrome, is known to cause progressive dystonia, with or without parkinsonism, among Filipino male adults with maternal roots from the Philippine island of Panay. We present cinematographic material of 11 cases of Lubag carrying the XDP haplotypes who manifest with a wide spectrum of movement disorders, including dystonia, tremor, parkinsonism, myoclonus, chorea, and myorhythmia. Because of overlapping features, Lubag patients are commonly misdiagnosed as idiopathic dystonia, essential tremor, Parkinson's disease, or Parkinson's-plus syndromes. Thus, it is imperative to elicit an exhaustive family history in any Filipino male adult who presents with a movement disorder. (Author)

Publication Type
Journal
Publication Sub Type
Others
Title
Movement Disorders
Frequency
Unknown
Publication Date
June 2002
Volume
17
Issue
6
Page(s)
1271-1277
LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Library Fulltext Print Format (Request Document)
U.S. National Library of Medicine: PubMed/Medline Abstract External Link (View)
U.S. National Library of Medicine: PubMed/Medline Fulltext pdf (Request Document)

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