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Submitted: 04 November 2010 Modified: 24 April 2019
HERDIN Record #: PCHRD11031003115463

Glucose-6-phosphate dehydrogenase deficiency in malaria endemic areas in the Philippines.

Crispin  P. Echiverri,
Myrna R. Acacio ,
Andres S. Cubacub ,
Marietta C. Baccay ,
Adoracion Z. Reyes ,
Fermin A. Talao ,
Nelia P. Salazar

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Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency, a hereditary biochemical defect of erythrocytes, was detected among residents of malaria endemic areas on the big island of Luzon, Republic of the Philippines. A total of 774 individuals were examined, 1.5 to 68 years old consisting of 485 males and 289 females. The overall prevalence rate of 5.5% among Filipinos concurred with data from previous studies. Pedigrees of selected families showed a Mendelian pattern of inheritance. The potential hazard of treating G-6-PD deficient patients with antimalarials such as primaquine, sulfonamide, sulfones, quinidine, and quinine, or combination thereof, is recognized.

Publication Type
Research Report
Date
LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Library Fulltext Print Format (Request Document)
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