Objective:This study is aimed at describing the demographic and clinical profile of patients diagnosed with HIV Infection / AIDS at De La Salle University medical center from May 2013 to May 2016.Design: A cross-sectional study review of medical records of patients who came in for HIV Screening and were tested positive for the first time from May of 2013 through May of 2016.Setting: De La Salle University Medical CenterSubjects: Patients who came in for HIV screening who tested positive for the first timefrom May 2013 through May 2016Methods:Patients' demographic and clinical data were retrieved from the Blood Bank of De La Salle University Medical Center. The names of the patients who tested positive were then searched in the Medical Records Section to determine whether the patient was admitted or not during the study period. Results:Results showed that more than half (53%) of patients who tested positive were age 21-30 years old and more than 90% were males. Most patients came in from Dasmarinas, Cavite (40.7%) and more than 80% were single. Ten percent (10%) of these patients work as call center agents. More than half of these patients are college graduate (53.4%). 24.5% of these patients claimed to be homosexuals. Patients who were subsequently admitted during the study period were noted at 34.7%. Dyspnea was the most common chief complaint upon screening (9.32%) while fever was the most common symptom upon admission. Candidiasis and Pneumocystis Carinii Pneumonia were the most common AIDS-defining conditions noted during admissions(55%). Most patients who were admitted were discharged stable (61%) while 17% expired during admission.Conclusion: This study has been consistent with the local data that the most commonly affected group are men who practice homosexual acts which is parallel to the global trend of shift of transmission from heterosexual to homosexual. A formal education even attainment of a college degree does not prevent transmission of this sexually-transmitted infection. This study therefore recommends directing screening strategies and consequence-oriented health education towards young men to middle age especially those working in the BPO industry in order to slow down the rise of this pandemic.I.