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Submitted: 10 February 2016 Modified: 10 February 2016
HERDIN Record #: R04A-DLSHSI-16021011370541

ACCURACY OF ABSOLUTE NEUTROPHIL COUNT AS A SCREENING TEST FOR URINARY TRACT INFECTION AMONG PEDIATRIC PATIENTS AGE 2 TO 24 MONTHS.

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OBJECTIVES: To determine the accuracy of Absolute Neutrophil Count in diagnosis of Urinary Tract Infection among Pediatric patients aged 2 to 24 months. DESIGN: Cross-sectional criterion study.SETTING: De La Salle University Medical Center PATIENTS: Pediatric patients between the ages of 2- 24 months, diagnosed with Urinary Tract Infection. MAIN OUTCOME MEASURE: A total of 168 patients were studied. Group 1 had positive growth (97 patients) and group 2 had negative growth (71 patients).  Diagnostic accuracy of ANC was evaluated thru determination of sensitivity, specificity, positive and negative likelihood ratio at 95% confidence interval. Confounding variables (pyuria, hematuria, bacteriuria) was correlated with ANC in diagnosis of UTI. RESULTS: Majority of patients diagnosed with UTI were aged 2 - 6 months, with slight female predominance. Chief complaints were fever, vomiting, diarrhea, dysuria and seizure. Associated symptoms were poor feeding and irritability.  Pyuria and bacteriuria were mostly seen, and only 1 patient had hematuria. Hematologic profile showed leukocytosis, increased segmenter counts and lymphocytosis. Band cells were found only in 80 (47.62%) patients. This study showed increased in the specificity of ANC when combined with pyuria and bacteriuria and a 100% specificity of ANC when combined with hematuria. However, the sensitivity and diagnostic accuracy of ANC and all other confounding variables were low. CONCLUSION: Absolute neutrophil count alone cannot be used as a screening test for diagnosing UTI in young children because of its low diagnostic accuracy even when combined with other variables such as pyuria, hematuria & bacteriuria. Hence, urine culture should remain as the gold standard in diagnosis of UTI among febrile patients ages 2 - 24 months. KEYWORDS: absolute neutrophil count (ANC), Urinary Tract Infection (UTI), pediatric patients    

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Research Project
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Objectives

To determine the accuracy of Absolute Neutrophil Count in diagnosis of Urinary Tract Infection among Pediatric patients aged 2 to 24 months.

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