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Submitted: 10 February 2016 Modified: 10 February 2016
HERDIN Record #: R04A-DLSHSI-1602101105246

The clinical significance of platelet count among pediatric patients with Nephrotic Syndrome.

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ABSTRACT Objectives : To determine the relationship of initial platelet count between pediatric patients with steroid responsive and steroid non responsive nephrotic syndrome Design : A case control study Patients : Patients with Idiopathic Nephrotic Syndrome aged 1-18 years old Methods : Demographic, hematologic, serologic and urinalysis findings were retrieved. Patients were grouped into, group A (steroid non responsive) and group B (steroid responsive). Comparison of initial platelet count between group A and group B were analyzed.  Results : Ninety patients with Idiopathic Nephrotic Syndrome were included in the study. Forty-five patient belong to group A while group B had 45 patients. Most of the patients belong to the 1-5 years old age. Fifty-seven (63.3%) were males and 33 (36.7%) females with a 1.7:1 male to female ratio. Most patients consulted because of edema. Anemia (53.2%), leukocytosis (75.6%), thrombocytosis (51.1%) were noted. Fisher's exact test showed that there is a statistically significant difference in the platelet count between steroid non responsive and steroid responsive nephrotic children.Conclusion : Nephrotic children with increased platelet count are 1.3 times more likely to be steroid non responsive than those normal platelet count. Thus, close monitoring  follow up is highly recommended.

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Research Project
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Objectives

Objectives : To determine the relationship of initial platelet count between pediatric patients with steroid responsive and steroid non responsive nephrotic syndrome Design : A case control study Patients : Patients with Idiopathic Nephrotic Syndrome aged 1-18 years old

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