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Submitted: 16 December 2014 Modified: 16 December 2014
HERDIN Record #: NCR-UERMMMC-14121606383270

The use of human placenta extract in the promotion of wound healing: an experimental study in rabbits

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Methods: Twenty healthy male albino New Zealand rabbits weighing 1.8 to 2kgs. were used in this study. Each rabbit has two wounds 2x2 cm prepared on each flank. One side was painted with human placenta extract (experimental group) and the contralateral side, with saline (control group) daily for 7 to 10 days post-operatively. The wound was inspected daily for granulation tissue formation. Tissue samples were obtained on the 10th post-operative day and examined for cellular infiltration, collagen deposition and arrangement. 


Results: Fourteen out 20 (70%) wounds in the experimental group had complete healing on the 7th post-operative day while 14/20 (70%) wounds in the control group had only moderate healing and was statistically significant. All the wounds in the experimental group showed granulation tissue formation on the 6th post-operative day while the same percentage was achieved on the 8th day in the control group, which is statistically significant. Nineteen out of 20 (95%) wounds in the control group had mild cellular infiltration while 14/20 (70%) wounds in the experimental group had moderate collagen deposition on the 10th post-operative day while 12-20 (60%) wounds in the control group had mild deposition, also statistically significant.


Conclusion: Human placenta extract made an impact on the extent and rate of granulation tissue deposition compared to saline-treated wounds in rabbits. Likewise, the study showed that it resulted in less inflammatory reaction but more collagen deposition in a more parallel arrangement.

Publication Type
Journal
Publication Sub Type
Journal Article, Original
Title
Health Sciences Journal
Frequency
Others
Publication Date
April-September 2012
Volume
1
Issue
1
Page(s)
70-76

Objectives

A primary concern in the post-operative period is wound healing and with it, the rate at which wound healing can be achieved. Many have comprehensively pursued efforts to come up with treatment modalities to bring about the acceleration of wound healing and one this is human placenta extract. This study aimed to determine whether or not human placenta extract accelerated wound healing and produce a cosmetically acceptable scar as well. 

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