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Submitted: 16 May 2007 Modified: 04 March 2019
HERDIN Record #: PCHRDPC020727

Initial characterization of the GH-IGF axis and nutritional status of the Ati Negritos of the Philippines.

 Ho KK,
 Ambler GR,
 Al-Toumah B,
 Baxter RC,
 Cowell CT,
 Coakley JC,
 Clavano-Harding AB,
 Garnett SP

BACKGROUND AND OBJECTIVE: The Ati Negritos are a Pygmy-like aboriginal population from the Philippines with physical characteristics of short stature, dark skin and woolly, kinked hair. Their final height, components of their GH-IGF axis and various nutritional markers are described.


SUBJECTS, DESIGN AND MEASUREMENTS: Auxological data and sera for the components of the GH-IGF axis and nutritional parameters were collected from 9 adult Ati Negritos in their native environment and 10 Filipinos in Sydney.


RESULTS: The height SDS (-3.66 +/- 1.1 vs. -1.01 +/- 1.20), weight SDS (-2.30 +/- 1.6 vs. 0.10 +/- 0.7), and BMI SDS (-1.4 +/- 1.8 vs. -0.2 +/- 0.5) between the two groups were significantly different (P< 0.01). The mean height of the 6 male Ati negritos was 149 +/- 7 and 144 +/- 3 cm for the females and are comparable with the African Pygmies and the Mountain Ok people of Papua New Guinea. Th Ati Negritos showed lower growth hormone binding protein (GHBP), insulin-like growth factor I (IGF-I), insulin-like growth factor binding protein 3 (IGFBP-3), acid labile subunit (ALS), zinc albumin, ferritin, iron, iron saturation and much higher insulin-like growth factor binding protein 2 (IGFBP-2) and plasma transferrin concentrations. No differences were noted in random growth hormone (GH), plasma insulin-like growth factor II (IGF-II), nor in their plasma concentrations of prealbumin, thyroid stimulating hormone (TSH) and free thyroxine(T4).


CONCLUSION: Perturbations of both the GH-IGF-I axis and nutritional markers exist in the Ati Negritos. These findings may be determinants of their stature; however, the aetiology of these changes remains to be fully elucidated. (Author)

Publication Type
Journal
Publication Sub Type
Others
Title
Clin Endocrinol (Oxf)
Frequency
Annual
Publication Date
December- 1999
Volume
51
Issue
6
Page(s)
741-7
LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Library Abstract Print Format (Request Document)
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U.S. National Library of Medicine: PubMed/Medline Abstract External Link (View)

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